AFI+™ treatment - a revolution in skin regeneration by Cell Culture at MediDerm Clinic

Marvie Hotel & Health guests in search of top-notch services of anti-aging and regenerative medicine, regularly express confidence in our partner – MediDerm Clinic – active for over 20 years and boasting almost over 40,000 successful procedures. This anti-aging clinic for dermatology and aesthetic medicine is set on preventing premature ageing as well as various diseases by applying a modern diagnostic and therapeutic approach.
As of recently, the clinic provides its clients with the most effective skin rejuvenation treatment available today AFI+™, all within the facilities of Marvie Hotel & Health.

Autologous Fibroblast Injection method - a revolution in skin regeneration

The innovative AFI+™, which stands for Autologous Fibroblast Injection method, is now accessible at MediDerm Clinic and provided by the clinic’s collaboration with Cell Culture Lab.

This state-of-the-art procedure reverses the process of facial skin ageing via the injection of own fibroblasts with the aim of replacing the ones lost over time. Fibroblasts play an essential role in the maintenance of skin elasticity and hydration while also synthesising collagen to ensure skin firmness.

The method has already proven to be more effective than standard aesthetic procedures as a single injection shows effects that can last for years. Autologous Fibroblast Injection is also highly recommended by many dermatologists for its personalised nature.

A procedure available exclusively in Split, Croatia

The highly effective Autologous Fibroblast Injection (AFI+™) method is still a hardly accessible procedure, and while it is available in clinics around Asia as well as the USA, Split is the only location in Europe where this clinically approved treatment has already been adopted.

With the aim of moving the skin industry’s focus towards health rather than aesthetics, Dr. Francois-Xavier Pellay, Ph.D., a specialist in the field of ageing and regeneration, has co-founded Cell Culture Lab. This skin rejuvenation laboratory is based in Split, at The Mediterranean Institute for Life Sciences – MediLS, where all the cells are cultivated and prepared for injection, while the treatment is performed via Cell Culture’s Lab collaboration with MediDerm Clinic, and takes place within the facilities of Marvie Hotel & Health.

Skin ageing over the years

Take three steps to reach impressive results

To begin the AFI+™ treatment, patients schedule a visit with MediDerm at the clinic’s facilities within Marvie Hotel & Health.

MediDerm Clinic within Marvie Hotel & Health

The first stage of the process consists of a 3mm biopsy. A small fragment of skin containing healthy cells is selected. The chosen cells most frequently belong to the hidden area behind the earlobes where the skin is well vascularized, but biologically younger than one’s own facial skin cells, as this skin area does not endure frequent sun exposure and therefore is not susceptible to photo-ageing.

The very biopsy is a completely painless procedure performed under local anaesthesia, while a potential small bruise heals within a couple of days. Following this process, the patients are free to continue their daily activities and can safely enter pools, wellness areas, and engage in walks.

At this stage, the sampled tissues collected during the biopsy are sent to MEDILS, i.e. to Cell Culture Lab in Split, where the cells are cultivated for a month. When the rejuvenating fibroblasts have been multiplied and are ready to be injected into the patient’s skin, the laboratory will send a written confirmation specifying the number and quality of obtained cells.

At this point the actual treatment session can take place. The cultivated fibroblasts can be used immediately, by injection into the areas of the skin that require treatment. Otherwise there is also the possibility of cryopreservation for a later injection

When ready to start the treatment, patients are invited to select the time and date when this third stage of the procedure can take place. The treatment will be carried out within the facilities of MediDerm clinic at Mervie Hotel & Health. During this process, the cultivated cells are injected into the skin areas that have been previously selected by the patient and specialist as in need of rejuvenation due to present wrinkles or other skin imperfections, such as scarred tissues or acne scars. 

The implementation of the cells is performed with a 6mm micro-needle and is completely painless. Following the application of fibroblasts the patients are advised not to be exposed to sunlight and avoid flying within the same day of the procedure, as to reduce the risk of infection and allow the skin to rest.

What makes AFI+™ treatment unique?

Autologous Fibroblast Injection (AFI+™) can be considered a game changer in the field of skin rejuvenation. What sets it apart from many other treatments available on the market is the process of isolating the patients’ own skin cells and the following personalised implementation of cultivated fibroblasts. Therefore, the method consists of a natural rejuvenation process by which patients have the possibility of successfully dealing with fine wrinkles, pigmentation, or scarring. Furthermore, no chemical substances, such as hyaluronic acid or botulinum toxin, are used in the course of the treatment. The latter implies the absence of possible allergic reactions or granuloma formation, while only a small local bruise may appear post-biopsy.

Another advantage of the AFI+™ treatment is that its results last for years. Following this procedure, its successful outcomes will be visible even after 5 years! The lasting effects of AFI+™ are therefore substantially longer than what is usually achieved with hyaluron fillers, which last around 1 year, or botox, the results of which wear off after 3 to 4 months. 

Before & after AFI+™ treatment

Over the weeks following the treatment, the first results will gradually become apparent and will keep on improving over the following months, while after 3 to 6 months the outcome will be completely visible. The treated areas of the skin will achieve freshness, elasticity, the fading of treated wrinkles and an overall healthier and younger appearance.

One treatment only is enough to include all the areas of the face one wishes to improve and  rejuvenate. Unlike botox procedures where only one area of the face is treated per session, the AFI+™ method allows specialists to work on the whole face, including the forehead, the eye area, or perhaps even the neck and décolletage, the hands, as well as all other skin areas prone to photo-ageing, all in one treatment session only!

What should also be kept in mind is that should one want to repeat the procedure after a number of years, there will no longer be need for another biopsy as the cells for cultivation have already been retrieved during the first treatment.

It is important to highlight that initial consultations with specialists at MediDerm should be kept realistic. Patients will be informed on what one can realistically expect from the procedure and explanations will be given on what can be achieved.

The cost of this entire three-stage procedure is 4500 EUR, a great offer when compared to costs ranging from 10 000 to 20 000 USD for the same treatment in clinics around the USA. Please be advised that the entirety of the fee is to be covered during the first stage of the procedure, as to ensure the cultivation process. Payment can be made via card, cash or bank transfer.

The takeaway

The Autologous Fibroblast Injection (AFI+™) method is an innovative procedure of skin rejuvenation with a long-lasting effect which improves both the health and appearance of treated skin areas for periods up to 5 years. 

The procedure is safe and stands out in comparison to other skin-rejuvenation methods due to its use of the patients’ own healthy fibroblasts which are retrieved via biopsy and cultivated for later implementation to damaged or photo-aged skin areas. It has proved to be effective for dealing with wrinkles, pigmentation, and scars

In Europe, the treatment is available exclusively in Split, at Marvie Hotel & Health, as a result of the successful collaboration of the hotel’s partner MediDerm Clinic and the Cell Culture Lab, based at The Mediterranean Institute for Life Sciences – MediLS. 

For further information on the AFI+™ treatment, feel free to contact us via info@poliklinika-mediderm.com, and plan your relaxing stay at Marvie Hotel & Health by booking@marviehotel.com.

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